Based on the National Patent Database to analyze the medication rule of Traditional Chinese Medicine compounds for the treatment of colorectal cancer
10.3760/cma.j.cn115398-20210106-00043
- VernacularTitle:基于国家专利数据库分析中药复方治疗大肠癌用药规律
- Author:
Menglong ZOU
1
;
Xiaoyan HUANG
;
Yalu CHEN
;
Xin NING
;
Renjun MENG
;
Shumin YU
Author Information
1. 广西中医药大学研究生院，南宁 530001
- Keywords:
Data mining;
Compounds (TCD);
Colorectal cancer;
National patent database;
Medication rule
- From:
International Journal of Traditional Chinese Medicine
2022;44(6):680-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Based on the National Patent Database, this paper analyzes the medication rule of Traditional Chinese Medicine (TCM) compound patents for the treatment of colorectal cancer in the past 10 years.Methods:By searching for and extracted screening out TCM compound patents for the treatment of colorectal cancer and after the dada selection, data entry , data specifications, the compound patents database for the treatment of colorectal cancer was established. then used IBM SPSS Modeler and IBM SPSS Statistics software to perform frequency analysis, attribute analysis, association analysis and cluster analysis of TCM.Results:A total of 97 compound patents were included, including 411 TCM, among which the core medicines are Atractylodis macrocephalae rhizoma, Hedyotis diffusa, Astragali radix, Glycyrrhizae radix et rhizoma, Scutellariae barbatae herba, Poria, etc. The medicine is mainly cold and warm; The medicine mainly tastes bitter and sweet; The spleen meridian is the main meridian. The cluster analysis result shows there are 7 categories, and the paired TCM with strong correlation includes Hedyotis diffusa- Scutellariae barbatae herba, Atractylodis macrocephalae rhizoma- Curcumae rhizoma, Astragali radix- Codonopsis radix and so on. Conclusions:Treating colorectal cancer should take those medicine which could invigorate the spleen and nurture the deficiency, such as Atractylodis macrocephalae rhizoma, Astragali radix, Codonopsis radix, while for clearing away heat, detoxifying, promoting blood circulation and removing blood stasis, such as Hedyotis diffusa, Scutellariae barbatae herba, and Curcumae rhizoma. At the same time, it can be combined as appropriate, attacking and replenishing simultaneously, regulating qi and blood.
