Mechanism and clinical significance of YAP in the progression of gastric cancer

VernacularTitle:YAP在胃癌进展中的作用机制及临床意义
Author: Jiahui CAI ¹ ; Guanghong RONG
Author Information

1. 青海大学研究生院，西宁　810000
Keywords: Gastric neoplasms; Yes-associated protein; Hippo pathway
From: Journal of International Oncology 2022;49(11):687-691
CountryChina
Language:Chinese
Abstract: Gastric cancer is one of the common malignant tumors with a high incidence in China. With the deepening of the research on tumor molecular biology, molecular targeted therapy has shown its advantages, and immunotherapy has attracted much attention. Yes-associated protein (YAP) is an effector protein that plays a major role in Hippo pathway, and it can regulate the growth of cells after binding with transcription factors in the nucleus. In recent years, many studies have shown that the high expression of YAP is closely related to the occurrence, development and metastasis of gastric cancer, and may be an important target of chemotherapy resistance. The further study can provide reference for clinical treatment.