Role of cancer-associated fibroblasts in the development and progression of breast cancer

VernacularTitle:肿瘤相关成纤维细胞在乳腺癌发生与发展中的作用
Author: Wenhao WANG ¹ ; Xirui SUN ; Jin LIU ; Xiumei SUN
Author Information

1. 潍坊医学院附属医院肿瘤科，潍坊　261041
Keywords: Tumor microenvironment; Cancer-associated fibroblasts; Breast neoplasms; Exosomes
From: Journal of International Oncology 2022;49(10):615-618
CountryChina
Language:Chinese
Abstract: Recent studies have shown that tumor microenvironment (TME) is significantly different from normal tissues, such as the change of abnormal enzyme expression, hypoxia, pH and so on. TME is closely related to the induced proliferation of tumor cells, angiogenesis, immune escape and the production of multidrug resistance. Cancer associated fibroblasts (CAFs) are the main stromal cell types in the TME. A variety of cytokines secreted by CAFs play an important role in tumor growth, invasion and metastasis. Understanding the role and mechanism of CAFs in the development of breast cancer is expected to provide a new target for improving the prognosis of breast cancer patients.