Role of P4HA2 in promoting cancer progression
10.3760/cma.j.cn371439-20220623-00105
- VernacularTitle:P4HA2在促进肿瘤进展中的作用
- Author:
Yuli SONG
1
;
Yi ZHANG
Author Information
1. 中国医科大学附属第一医院妇科，沈阳 110001
- Keywords:
Neoplasms;
P4HA2;
C-P4H
- From:
Journal of International Oncology
2022;49(9):543-545
- CountryChina
- Language:Chinese
-
Abstract:
P4HA2, one of the important genes encoding the α subunit of collagen prolyl 4-hydroxylase (C-P4H) , is overexpressed in a variety of tumors and promotes tumor progression, and its high expression correlates with the poor prognosis of patients. In different tumors, P4HA2 can promote the proliferation, migration and invasion of tumor cells, increase the proportion of cancer stem cell population, and promote tumor cells to escape from immune system. An in-depth understanding of the role of P4HA2 in tumor progression may provide new ideas and insights for targeting P4HA2 to prevent or reverse tumor progression.
