Mechanism of FOXA2 in colorectal cancer and its application in diagnosis and treatment
10.3760/cma.j.cn371439-20220429-00094
- VernacularTitle:FOXA2在结直肠癌中的作用机制及其在诊疗中的作用
- Author:
Mengpan HUANG
1
;
Xuehong WANG
;
Yongfu LU
Author Information
1. 青海大学研究生院，西宁 810016
- Keywords:
Colorectal neoplasms;
Forkhead box protein;
FOXA2
- From:
Journal of International Oncology
2022;49(8):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Forkhead box protein A2 (FOXA2) , characterized by its unique DNA binding domain, plays a key role in transcriptional regulation. FOXA2 transcription factor is highly expressed in colorectal cancer, and binds with corresponding targeted genes to regulate tumor growth and inflammatory response, thus playing the role of oncogenes. In-depth understanding of the role and function of human FOXA2 transcription factor in colorectal cancer will contribute to further development of FOXA2 as a potential therapeutic target and diagnostic and prognostic marker of colorectal cancer.
