Methyltransferase like protein 14 and tumor
10.3760/cma.j.cn371439-20220511-00092
- VernacularTitle:甲基转移酶样蛋白14与肿瘤
- Author:
Ru HU
1
;
Donglin LI
;
Xuebing YAN
Author Information
1. 扬州大学附属医院肿瘤科，扬州 225000
- Keywords:
Neoplasms;
N 6-methyladenosine;
Methyltransferase like protein 14;
Signaling pathway;
Biomarkers
- From:
Journal of International Oncology
2022;49(8):478-483
- CountryChina
- Language:Chinese
-
Abstract:
N 6-methyladenosine (m 6A) modification, as the most prevalent epigenetic modification of RNA, plays a crucial role in the initiation and development of malignancies. Methyltransferase like protein 14 (METTL14) is a major methylase catalyzing m 6A modification and regulating biological processes such as RNA splicing, translation and degradation. Recent studies have demonstrated that METTL14 not only regulates the growth, invasion and metastasis of tumors through various molecular mechanisms, but also is closely correlated with the prognosis of tumor patients and clinical efficacy of anti-tumor therapies. In-depth understanding of the mechanism of METTL14 in breast, digestive system and urinary system tumors is helpful to provide new clinical markers and drug targets for the prevention and treatment of tumors based on m 6A modification.
