Research progress of avermectins in anti-tumor
10.3760/cma.j.cn371439-20220321-00067
- VernacularTitle:阿维菌素类药物在抗肿瘤方面的研究进展
- Author:
Liwei WANG
1
;
Hongsheng LIANG
;
Songlin DU
;
Zhihao CHEN
;
Qing WANG
;
Aili GAO
Author Information
1. 东北农业大学生命科学学院，哈尔滨 150030
- Keywords:
Antineoplastic agents;
Molecular mechanisms of pharmacological action;
Avermectins
- From:
Journal of International Oncology
2022;49(6):353-356
- CountryChina
- Language:Chinese
-
Abstract:
Avermectins can affect biological processes of multiple tumor, including tumor cell proliferation and metastasis, cell cycle arrest, induction of apoptosis and autophagy, regulation of tumor microenvironment and tumor stem cells. Avermectins can be administered alone or combined with chemotherapeutic drugs to reverse multidrug resistance. To further explore the anti-tumor mechanism of avermectins will provide reliable experimental and theoretical guidance for future clinical application.
