Research progress of circadian clock genes in hepatocellular carcinoma
10.3760/cma.j.cn115396-20220622-00206
- VernacularTitle:生物钟基因在肝细胞癌中的研究进展
- Author:
Jun DING
1
;
Jifan XU
Author Information
1. 湖北省恩施土家族苗族自治州中心医院肝胆胰脾外科，恩施 445000
- Keywords:
Biological clocks;
Genes;
Circadian rhythm;
Hepatocellular carcinoma
- From:
International Journal of Surgery
2022;49(8):559-562
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm is mainly regulated by circadian clock genes, which is the result of biological evolution and plays an important role in maintaining the normal structure and function of organisms. When the circadian rhythm is disturbed or out of balance, it will have adverse health consequences. In addition to studies on diseases of nervous system, endocrine system or cardiovascular system, it has been found that circadian rhythm disorder mediated by circadian clock gene also plays a key regulatory role in the occurrence and development of hepatocellular carcinoma, which is a potential diagnostic marker and therapeutic target. In this paper, the research on the role of circadian clock gene in hepatocellular carcinoma in recent years is reviewed, and the research progresis and existing problems of targeting circadian clock gene in the treatment of hepatocellular carcinoma are discussed.
