Retrospective analysis of clinical features and prognosis of breast encapsulated papillary carcinoma based on SEER database
10.3760/cma.j.cn115396-20220117-00024
- VernacularTitle:基于SEER数据库回顾性分析乳腺包裹性乳头状癌的临床特征及预后
- Author:
Wenyan WANG
1
;
Tie ZHANG
;
Qiang ZHU
;
Pilin WANG
Author Information
1. 首都医科大学附属北京天坛医院乳腺科，北京 100070
- Keywords:
Breast neoplasms;
Encapsulated papillary carcinoma;
Risk factors;
Prognosis
- From:
International Journal of Surgery
2022;49(6):381-387,F3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinicopathological features, survival and related prognostic factors of encapsulated papillary carcinoma (EPC) of breast.Methods:Data on EPC and invasive ductal carcinoma (IDC) of the breast from January 2010 to December 2015 were searched and screened using the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to adjust for baseline confounding between the EPC and IDC groups. The Kaplan-Meier method was used to calculate cumulative survival curves for overall survival (OS) and breast cancer-specific survival (BCSS). Prognostic value of these factors were assessed by univariate Log-rank test and multivariate Cox regression analysis.Results:In this study, 184 524 patients with IDC and 175 patients with EPC were included. Compared with patients with IDC, patients with EPC over 60 years old had a higher proportion, a lower rate of lymph node metastasis, and a higher proportion of estrogen receptor positive, progesterone receptor positive and human epidermal growth factor receptor 2 negative ( P<0.05). After PSM adjustment, OS of patients with EPC was worse than that of IDC, and BCSS was better than that of IDC ( P<0.05). Univariate and multivariate analysis showed that age, surgical approach and N stage were associated with poorer OS, while surgery approach, T stage, N stage and molecular typing were associated with worse BCSS ( P<0.05). Conclusions:Compared with IDC, EPC of breast has better BCSS and lower lymph node metastasis rate. There is a certain correlation between tumor stage and molecular type and prognosis of EPC.
