Research progress in the role of HMGB1-RAGE signaling axis in hepatic ischemia-reperfusion injury
10.3760/cma.j.cn121382-20211012-00213
- VernacularTitle:HMGB1-RAGE信号轴在肝脏缺血再灌注损伤中作用的研究进展
- Author:
Li ZHAO
1
;
Zilin CUI
;
Yamin ZHANG
;
Jie LIU
Author Information
1. 天津市第三中心医院分院普通外科，天津 300250
- Keywords:
High mobility histone 1;
Glycation end product receptor;
Hepatic ischemia-reperfusion injury
- From:
International Journal of Biomedical Engineering
2022;45(2):166-170,185
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury(HIRI) is a kind of liver injury caused by reperfusion after ischemic injury, which is clinically manifested by a series of deterioration phenomena such as liver function impairment, jaundice and even multi-organ failure after restoration of blood supply to the liver. HIRI seriously affects the patient's regression and prognosis. The essence of HIRI is a sterile inflammatory response. High mobility histone 1 (HMGB1) is an important intermediate mediator of HIRI and is a multiple cell type effector involved in HIRI. The receptor for glycosylated end products(RAGE) signaling axis of HMGB1 plays a key role in HIRI, but its mechanism is unclear. In this paper, the recent studies related to the pro-inflammatory mechanism of HMGB1-RAGE signaling axis in HIRI were summarized, and the relationship between HMGB1-RAGE signaling pathway and HIRI was discussed. The research progress of preventing and treating HIRI with surgical operation, ischemic preconditioning, drug and gene therapy using HMGB1-RAGE signaling axis as the target was reviewed.
