Research progress in detection of lung cancer tumor markers by biosensors
10.3760/cma.j.cn121382-20210805-00212
- VernacularTitle:肺癌肿瘤标志物生物传感器检测研究进展
- Author:
Yinglin WANG
1
;
Yafang WU
;
Zhiqiang HUANG
;
Yachen TIAN
;
Jiaye JIANG
;
Xiaotian HUANG
;
Qing LIU
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Lung cancer tumor markers;
Biosensor;
Detection technology
- From:
International Journal of Biomedical Engineering
2022;45(2):157-165
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the malignant tumors with the highest morbidity and mortality rate, and effective screening and early diagnosis methods can significantly reduce the morbidity and mortality rate of lung cancer patients. Traditional lung cancer detection methods mainly include imaging tests, sputum cell tests, bronchoscopy, and needle biopsy, but these methods have disadvantages such as being highly invasive, complicated operation processes, prone to false positives, and low detection index. Tumor markers can reflect the occurrence and development of tumors and can monitor the effect of tumor treatment. Therefore, tumor marker detection is of great significance for early cancer diagnosis. Biosensor technology is a new rapid detection technology with promising applications. In recent years, research related to biosensors has been intensified in clinical testing and biomedicine. In this paper, the traditional detection methods for lung cancer were briefly introduced, and the technologies and detection methods related to optical or electrochemical lung cancer tumor marker biosensors based on immunology, nanomaterials, and aptamers were highlighted in recent years, and the future development trend of lung cancer tumor marker biosensors was prospected.
