Research progress in the application of polydopamine multifunctional nanocontrast agents in molecular imaging of tumors
10.3760/cma.j.cn121382-20210906-00117
- VernacularTitle:聚多巴胺多功能纳米造影剂在肿瘤分子影像中的应用进展
- Author:
Xue LI
1
;
Menglin WU
;
Qi GUO
;
Jiang LI
;
Xuening ZHANG
Author Information
1. 天津医科大学第二医院医学影像科，天津 300211
- Keywords:
Nanocontrast agents;
Polydopamine;
Biomimetic materials;
Tumor molecular imaging
- From:
International Journal of Biomedical Engineering
2022;45(1):80-85
- CountryChina
- Language:Chinese
-
Abstract:
The development of multifunctional nanocontrast agents with high sensitivity, high specificity, and low toxicity so that they can precisely localize tumors and reflect tumor biological information in real time is the core of promoting the development of tumor molecular imaging technology and realizing early and precise tumor diagnosis. Polydopamine (PDA) nanomaterials are bionanomaterials with a structure extremely similar to that of natural melanin. They can be easily fabricated and functionalized, and can achieve controlled assembly of functional molecules such as contrast components and targeting ligands via metal coordination, π-π stacking, electrostatic adsorption, and other methods. They have good biocompatibility and biodegradability, show great potential for clinical translation, and have been widely used in molecular imaging of tumors. In this review paper, the preclinical studies of PDA nanoparticles are reviewed as well as the synthesis methods, functionalized modification, and assembly strategies of PDA nanoparticles and their applications in tumor molecular imaging. The development trends of PDA are also presented to promote their application in the field of tumor molecular imaging.
