Expression of minichromosome maintenance protein 6 (MCM6) in colon cancer tissues and its correlation with proliferating cell nuclear antigen (PCNA)
10.3760/cma.j.cn121382-20210911-00110
- VernacularTitle:微小染色体维持蛋白6（MCM6）在结肠癌组织中的表达及其与增殖细胞核抗原（PCNA）的相关性
- Author:
Dongyu ZHAO
1
;
Yonggang GUO
;
Hong SHEN
;
Yun ZHANG
Author Information
1. 中国人民武装警察部队特色医学中心，特勤急救外科（消化外科），天津 300162
- Keywords:
Minichromosome maintenance protein 6 (MCM6);
Colon cancer;
Clinicopathological features;
Tumor staging;
Proliferating cell nuclear antigen (PCNA)
- From:
International Journal of Biomedical Engineering
2022;45(1):41-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression level of minichromosome maintenance protein 6 (MCM6) in colon cancer tissues, the correlation between the expression level of MCM6 and the clinicopathological characteristics of colon cancer patients, and the correlation between MCM6 and PCNA expression.Methods:The expression levels of MCM6 in different tumor tissues were analyzed based on the Human Protein Atlas (HPA) database. The expression levels and correlations of MCM6 and PCNA in colon cancer tissues were analyzed based on The Cancer Genome Atlas (TCGA) database and immunohistochemical experiments. The correlation between MCM6 expression level and clinical characteristics of colon cancer patients was analyzed. The correlation between MCM6 and PCNA expression in colon cancer was analyzed based on TCGA database and Gene Expression Profile Interaction Analysis (GEPIA) database.Results:Bioinformatics analysis and immunohistochemical results confirmed that MCM6 was highly expressed in colon cancer tissues, and its expression level was correlated with the tumor stage of patients ( P=0.01). In colon cancer, the expression of MCM6 and PCNA was correlated with statistical significance ( P<0.05). Conclusions:MCM6 is highly expressed in colon cancer tissue and is related to the clinical characteristics of patients, suggesting that MCM6 can be used as a potential marker of colon cancer.
