Microglia: a potential intervention target for vascular cognitive impairment
10.3760/cma.j.issn.1673-4165.2022.08.012
- VernacularTitle:小胶质细胞：血管性认知损害的潜在干预靶点
- Author:
Yining XIAO
1
;
Tianyuan GUAN
;
Peiyuan LYU
Author Information
1. 河北医科大学研究生院，石家庄 050017
- Keywords:
Cognition disorders;
Cerebrovascular disorders;
Microglia;
Inflammation;
Oxidative stress;
Blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2022;30(8):626-630
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are the main innate immune cells in the central nervous system, which play a variety of roles in the development of the central nervous system and the occurrence of diseases. Recent studies have found that microglia play an important role in the occurrence and development of vascular cognitive impairment (VCI), which can lead to cognitive decline by activating neuroinflammation, oxidative stress, and destroying the blood-brain barrier. This article reviews the role of microglia in the pathophysiology of VCI, aiming to provide a new basis for targeting microglia to treat VCI.
