YKL-40 at admission predicts stroke-associated pneumonia and outcome in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.08.002
- VernacularTitle:入院时YKL-40预测急性缺血性卒中患者的卒中相关性肺炎和转归
- Author:
Guomei SHI
1
;
Xiaorong WANG
;
Wu XU
;
Minwang GUO
;
Meng WANG
;
Pengyu GONG
;
Junshan ZHOU
;
Rujuan ZHOU
Author Information
1. 泰兴市人民医院神经内科，泰州 225400
- Keywords:
Stroke;
Brain ischemia;
Pneumonia;
Chitinase-3-like protein 1;
Treatment outcome;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2022;30(8):569-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of YKL-40 at admission on stroke-associated pneumonia (SAP) and poor outcome in patients with acute ischemic stroke (AIS).Methods:Patients with AIS admitted to Taixing People’s Hospital from February 2020 to March 2021 were enrolled prospectively. The poor outcome was defined as 3-6 points on the modified Rankin Scale at 90 d after onset. Multivariate logistic regression analysis was used to determine the independent predictors of SAP and poor outcome, and the predictive value of serum YKL-40 on SAP and poor outcome was evaluated by receiver operating characteristic (ROC) curve. Results:A total of 377 patients with AIS were enrolled. The median serum YKL-40 was 127.16 μg/L. One hundred and four patients (27.6%) had SAP, and 126 (33.4%) had poor outcomes at 90 d after onset. Multivariate logistic regression analysis showed that after adjusting for confounding factors, YKL-40 was the independent predictors of SAP (odds ratio [ OR] 1.005, 95% confidence interval [ CI] 1.003-1.008; P=0.001) and poor outcome at 90 d ( OR 1.009, 95% CI 1.006-1.011; P=0.001). The ROC curve analysis showed that the area under the curve of YKL-40 for predicting SAP was 0.769 (95% CI 0.713-0.824; P<0.001), the best cutoff value was 168.70 μg/L, and the sensitivity and specificity were 71.2% and 75.1% respectively; the area under the curve of YKL-40 for predicting poor outcome at 90 d was 0.787 (95% CI 0.735-0.840; P<0.001), the best cutoff value was 195.56 μg/L, and the sensitivity and specificity were 68.3% and 84.1% respectively. Conclusion:Higher serum YKL-40 at admission has a good predictive value for SAP and poor outcome at 90 d in patients with AIS.
