Glymphatic system and cerebral edema after ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.06.010
- VernacularTitle:胶质淋巴系统与缺血性卒中后脑水肿
- Author:
Yaxin WEI
1
;
Shaojun WANG
Author Information
1. 延安大学咸阳医院神经内科，咸阳 712000
- Keywords:
Stroke;
Brain ischemia;
Brain edema;
Glymphatic system;
Aquaporin 4
- From:
International Journal of Cerebrovascular Diseases
2022;30(6):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Glymphatic system is a fluid transport and material clearance system found in recent years. It promotes the flow and exchange of cerebrospinal fluid and interstitial fluid, remove metabolic waste, and maintain the stability of the internal environment of the brain through the perivascular space and aquaporin 4 on astrocytes. Recent studies have shown that the glymphatic system plays an important role in the intake and discharge of the fluid in brain, and the changes of glymphatic system may be an important reason for brain edema after ischemic stroke. This article reviews the pathophysiological mechanism and related therapeutic targets of glymphatic system in the formation of cerebral edema after ischemic stroke, in order to provide new ideas for the treatment of cerebral edema after ischemic stroke.
