AMP-activated protein kinase signaling pathway: a potential therapeutic target for ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.06.009
- VernacularTitle:AMP活化蛋白激酶信号通路：缺血性卒中的潜在治疗靶点
- Author:
Si CHEN
1
;
Liping DONG
;
Yue ZHANG
;
Xiaoyan ZHANG
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Stroke;
Brain ischemia;
Reperfusion injury;
AMP-activated protein kinases;
Signal transduction
- From:
International Journal of Cerebrovascular Diseases
2022;30(6):448-454
- CountryChina
- Language:Chinese
-
Abstract:
AMP-activated protein kinase (AMPK) is an energy sensor, which can regulate the energy metabolism of cells by regulating mitochondrial oxidation capacity and substrate utilization, affecting various pathways such as glucose and fatty acid transport. Recent studies have shown that energy metabolism disturbance is a "blasting fuse" leading to a series of secondary injuries after cerebral ischemia-reperfusion, including oxidative stress, acidosis, apoptosis, and excitotoxicity. AMPK participates in most pathophysiological processes of cerebral ischemia-reperfusion injury by regulating cellular energy metabolism. This article reviews the mechanism of action of AMPK signaling pathway in cerebral ischemia-reperfusion injury.
