Role of inflammation in intracranial aneurysms and potential drug therapy
10.3760/cma.j.issn.1673-4165.2022.05.014
- VernacularTitle:炎症在颅内动脉瘤中的作用和潜在的药物治疗
- Author:
Wenxiang TANG
1
;
Shaochun YANG
Author Information
1. 赣南医学院第一附属医院神经外科，赣州 341000
- Keywords:
Intracranial aneurysm;
Inflammation;
Aspirin;
Hydroxymethylglutaryl-CoA reductase inhibitors;
Gastrointestinal microbiome
- From:
International Journal of Cerebrovascular Diseases
2022;30(5):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Intracranial aneurysm is a common cerebrovascular disease, which has a high morbidity and mortality after rupture, usually resulting in poor prognosis. Intracranial aneurysms are mainly treated by craniotomy clipping and endovascular embolization, but there is still controversy about whether the unruptured aneurysms with a diameter of <5 mm need intervention. Studies have shown that inflammation plays an important role in the formation, progression, and rupture of intracranial aneurysms. Aspirin and statins can delay the development of intracranial aneurysms and help reduce the risk of rupture through anti-inflammatory. This article reviews the inflammatory mechanism and potential drug therapy of intracranial aneurysms.
