Protective effect and mechanism of heme oxygenase-1 in atherosclerosis
10.3760/cma.j.issn.1673-4165.2022.05.012
- VernacularTitle:血红素加氧酶-1在动脉粥样硬化中的保护作用及其机制
- Author:
Yixing PAN
1
;
Zhu SHI
Author Information
1. 广东医科大学研究生院，湛江 524023
- Keywords:
Atherosclerosis;
Heme oxygenase-1;
Inflammation;
Oxidative stress
- From:
International Journal of Cerebrovascular Diseases
2022;30(5):380-385
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is closely associated with vascular diseases such as ischemic stroke and ischemic heart disease. Its main pathological mechanisms include inflammatory cell infiltration, oxidative stress, and vascular endothelial dysfunction. As an endogenous antioxidant enzyme, heme oxygenase-1 (HO-1) plays an anti-inflammatory, antioxidant and vasodilating role in the process of atherosclerosis, which can inhibit the occurrence of atherosclerosis and prevent the progress of unstable plaques. This article reviews the protective effect and mechanism of HO-1 in atherosclerosis, and discusses the important significance of HO-1 as a potential therapeutic target for atherosclerotic diseases.
