Correlation between serum lipocalin-2 and white matter hyperintensities in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.05.006
- VernacularTitle:血清脂质运载蛋白2与缺血性卒中患者脑白质高信号的相关性
- Author:
Zhenqian HUANG
1
;
Yun LI
;
Huaiming WANG
;
Ting WAN
;
Xiaohao ZHANG
;
Wusheng ZHU
;
Yi XIE
;
Xinfeng LIU
Author Information
1. 南京大学医学院附属金陵医院神经内科，南京 210002
- Keywords:
Stroke;
Brain ischemia;
White matter;
Lipocalin-2;
Magnetic resonance imaging;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2022;30(5):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the lipocalin-2 (LCN-2) level and white matter hyperintensities (WMHs) in patients with ischemic stroke.Methods:Consecutive patients with ischemic stroke admitted to the Department of Neurology, Jinling Hospital, Medical School of Nanjing University from September 2021 to November 2021 and whose duration from onset to hospitalization <14 d were prospectively enrolled. Enzyme-linked immunosorbent assay was used to detect the serum LCN-2. Fazekas scale was used to assess the severity of periventricular and subcortical WMHs. A total WMHs score ≥3 was defined as severe WMHs. Multivariate logistic regression analysis was used to determine the correlation between serum LCN-2 level and WMHs. Results:A total of 179 patients were enrolled, including 122 males (68.2%), aged 64.7±11.6 years. The median serum LCN-2 level was 387.1 g/L, and 86 patients (48.0%) had severe WMHs. Serum LCN-2 in the severe WMH group was significantly higher than that in the non-severe WMH group (505.3±342.4 g/L vs. 367.8±224.5 g/L; t=3.110, P=0.002). Multivariable logistic regression analysis showed that after adjusting for the relevant confounding factors, there was a significant correlation between higher serum LCN-2 and severe WMHs (odds ratio 2.32, 95% confidence interval 1.17-4.63; P=0.017) and higher total WMHs score (odds ratio 1.62, 95% confidence interval 1.12-2.35; P=0.011). Conclusion:Higher serum LCN-2 level is associated with severe WMHs in patients with ischemic stroke.
