Correlation between malnutrition and early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.05.002
- VernacularTitle:营养不良与急性缺血性卒中患者静脉溶栓后早期神经功能恶化的相关性
- Author:
Kejin YIN
1
;
Liqin LUAN
;
Xiaoli HUA
;
Xuejun WANG
;
Jian SUN
;
Chengfang WU
;
Wenbin WANG
;
Xiaoli PANG
Author Information
1. 南京江北医院神经内科 210000
- Keywords:
Stroke;
Brain ischemia;
Thrombolytic therapy;
Malnutrition;
Nutrition assessment;
Disease progression;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2022;30(5):327-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between malnutrition and early neurological deterioration (END) after intravenous thrombolysis in patients with acute ischemic stroke.Methods:Patients with ischemic stroke received intravenous thrombolysis in the Department of Neurology, Nanjing Jiangbei People's Hospital from January 2018 to December 2021 were retrospectively enrolled. Nutritional status was assessed by geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI). END was defined as an increase of ≥4 in the National Institutes of Health Stroke Scale score within 24 h after intravenous thrombolysis compared with the baseline value. The demographic and baseline clinical data of the patients in the END group and the non-END group were compared. Multivariate logistic regression analysis was used to determine the independent correlation between malnutrition and END. Results:A total of 256 patients were enrolled, including 156 males (60.9%), aged 65.6±12.0 years. According to GNRI and PNI, there were 122 (46.7%) and 62 (24.2%) patients with malnutrition respectively. END occurred in 37 patients (14.5%) during hospitalization. Multivariate logistic regression analysis showed that after adjusting for other confounding factors, there was a significant independent correlation between malnutrition and END after intravenous thrombolysis in patients with acute ischemic stroke (severe malnutrition as assessed by GNRI compared to normal nutritional status: odds ratio 5.736, 95% confidence interval 1.033-31.866, P=0.046; severe malnutrition as assessed by PNI compared to normal nutritional status: odds ratio 4.928, 95% confidence interval 1.589-15.282, P=0.006). Conclusion:Malnutrition is very common in patients with acute ischemic stroke and has a significant correlation with END after intravenous thrombolysis.
