Ferroptosis: a new target for the treatment of ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.04.012
- VernacularTitle:铁死亡：缺血性卒中治疗的新靶点
- Author:
Jing JIN
1
;
Lingling HU
;
Chaosheng LI
;
Tinggang WANG
;
Shuhua GUI
;
Chenyan SUI
;
Yumeng LIU
Author Information
1. 江南大学附属医院神经内科，无锡 214000
- Keywords:
Stroke;
Brain ischemia;
Ferroptosis;
Glutathione;
Glutathione peroxidase;
Lipid peroxidation
- From:
International Journal of Cerebrovascular Diseases
2022;30(4):308-312
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of programmed cell death that is closely associated with the pathophysiological process of ischemic stroke. Ferroptosis inhibitors can improve neurological function and provide neuroprotection after cerebral ischemia. Therefore, the role of ferroptosis in ischemic stroke and the regulation of ferroptosis to intervene in the occurrence and development of ischemic stroke have become a research hotspot. This article reviews the molecular mechanism and potential therapeutic targets of ferroptosis during ischemic stroke, hoping to provide new perspectives for the treatment of ischemic stroke.
