Advances in epidemiology and mechanism of azithromycin resistance in Salmonella
10.3760/cma.j.issn.1673-4408.2022.10.012
- VernacularTitle:沙门菌对阿奇霉素耐药的流行病学及机制研究进展
- Author:
Huijuan LIU
1
;
Hongmei WANG
;
Jikui DENG
Author Information
1. 深圳市儿童医院感染科 518038
- Keywords:
Salmonella;
Azithromycin;
Epidemiology;
Resistance mechanism
- From:
International Journal of Pediatrics
2022;49(10):699-702
- CountryChina
- Language:Chinese
-
Abstract:
Salmonella are important food-borne infectious bacteria causing gastroenteritis, enteric fever, bloodstream infection and focal extraintestinal infection and other salmonellosis.It is a major global public health problem.Antibiotics play an important role in the prevention and treatment of salmonellosis.With the emergence of resistance to traditional first-line drugs for the treatment of salmonellosis, azithromycin has become one of the commonly used antibiotics.However, studies have reported azithromycin resistant Salmonella strains, and azithromycin resistance in Salmonella is becoming more common and increasing year by year.Enhanced activity of active efflux pump, destruction of lactone ring structure, methylation of ribosome, carrying ICE_erm42 gene may be related mechanisms of drug resistance.The discovery, monitoring and in-depth study of azithromycin resistance in Salmonella play an important role in the rational use of antibiotics and delaying the trend of resistance.This article reviews the research progress on the epidemiology and related mechanisms of azithromycin resistance in Salmonella.
