Regulatory T cells and Kawasaki disease
10.3760/cma.j.issn.1673-4408.2022.10.004
- VernacularTitle:调节性T细胞在川崎病中的研究进展
- Author:
Jiawen XU
1
;
Yujia WANG
;
Fangqi GONG
Author Information
1. 浙江大学医学院附属儿童医院心血管内科，杭州 310052
- Keywords:
Regulatory T cells;
Kawasaki disease;
Immunosuppression
- From:
International Journal of Pediatrics
2022;49(10):663-667
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease is an acute, systemic vasculitis that easily injures coronary arteries and is the leading cause of acquired heart disease in children.Although the cause of Kawasaki disease remains unknown, it is widely believed that the pathogenesis of Kawasaki disease is an inflammatory cascade caused by a combination of infection and genetic predisposition.Regulatory T cells, which express Foxp3 + , CD4 + and CD25 + , are a T-cell subpopulation specialized in immune suppression.There are some correlations between regulatory T cells and Kawasaki disease in pathophysiology, treatment and prognosis.The dysfunction of regulatory T cells may be involved with the pathogenesis of Kawasaki disease, but there are few researches on it.This article reviews the progress of regulatory T cells in Kawasaki disease in recent years and summarizes the mechanism of regulatory T cells in the occurrence and repair of Kawasaki disease, prospecting the research future of targeted regulatory T cells therapy in the prevention of coronary artery lesions in Kawasaki disease.
