Progress in diagnosis and treatment of CC16 in children pulmonary disease
10.3760/cma.j.issn.1673-4408.2022.09.011
- VernacularTitle:克拉拉细胞分泌蛋白16在儿童肺部疾病诊治中的研究进展
- Author:
Li LI
1
;
Xingnan JIN
;
Xu WANG
;
Yingxue ZOU
Author Information
1. 天津市儿童医院（天津大学儿童医院）马场院区呼吸科 300074
- Keywords:
Children;
Clara cell secretory protein 16;
Clara cell;
Pulmonary disease
- From:
International Journal of Pediatrics
2022;49(9):625-628
- CountryChina
- Language:Chinese
-
Abstract:
Clara cell secretory protein 16(CC16)is one of the most important secreted proteins of Clara cells in respiratory epithelium, which mainly exists in the lining fluid of lung epithelial cells.When the bronchoalveolus-capillary membrane barrier is damaged, a large amount of CC16 will enter the blood.It′s eventually excreted in the urine.In recent years, more and more studies have found that CC16 not only has anti-inflammatory, immune-modulating, anti-oxidation and anti-fibrosis effects, but also is a sensitive indicator of the integrity of the airway epithelium, which can predict the occurrence and development of many children′s pulmonary diseases.This article mainly summarizes the biological characteristics and functions of CC16, and summarizes the research progress of CC16 in the diagnosis and treatment of pediatric pulmonary diseases.
