The clinical characteristics of the children with Epstein-Barr virus associated gastroenteritis
10.3760/cma.j.issn.1673-4408.2022.08.013
- VernacularTitle:儿童EB病毒相关胃肠炎临床特点分析
- Author:
Xiumin QIN
1
;
Guoli WANG
;
Jin ZHOU
;
Feihong YU
;
Jing ZHANG
;
Jie WU
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院消化内科 100045
- Keywords:
Children;
Epstein-Barr virus;
Gastroenteritis;
Clinical characteristics
- From:
International Journal of Pediatrics
2022;49(8):562-565,F3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics of Epstein-Barr(EB)virus associated gastroenteritis, aiming to improve the diagnosis and treatment.Methods:The clinical data of 8 patients diagnosed as EB virus associated gastroenteritis in Department of Gastroenterology, Beijing Children′s Hospital were retrospectively analyzed from January 2017 to December 2021 including the clinical data, laboratory examination, endoscopic and imaging findings, medications and clinical prognosis.Results:There were eight cases with the male: female ratio 6: 2, the average age 7.46 years, and history 20 d to 3 years.Main clinical manifestations were abdominal pain(7/8), diarrhea(4/8), bloody stools(3/8), fever(2/8), hematemesis(1/8), with the high load of serum EB virus DNA in 4 cases.The endoscopic features were rough mucosa, edema, erosion, boundary clear shallow ulcer.The EB virus-encoded small RNA(EBER)was positive in situ hybridization(8/8).The frequently affected sites were upper gastrointestinal tract(3/8), small intestine(2/8)and colon(4/8).The common complications were sepsis(3/8)and mild malnutrition(3/8).All patients became better by the enteral nutrition and antiviral therapy.Conclusion:The EB virus associated gastroenteritis is rare with the serious complications, the non-specific clinical manifestations.The clinical doctors should improve the understanding of this disease in order to improve the diagnosis and therapy.Clinicians should pay more attention to the test of EB virus in serum and membrane, then carry out the accurate treatment.
