Significance of fecal calprotectin and eosinophil-derived neurotoxin in non-IgE-mediated food allergy
10.3760/cma.j.issn.1673-4408.2022.08.006
- VernacularTitle:粪便钙卫蛋白和嗜酸性粒细胞源性神经毒素在非IgE介导的食物过敏中的意义
- Author:
Xiaoqian YAN
1
;
Yu JIN
Author Information
1. 南京医科大学附属儿童医院消化科 210008
- Keywords:
Food allergy;
Non-IgE-mediated;
Fecal calprotectin;
Fecal eosinophil-derived neurotoxin
- From:
International Journal of Pediatrics
2022;49(8):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Non-IgE-mediated food allergy most often presents with gastrointestinal symptoms such as diarrhoea, mucus stools, bloody stools, reflux and vomiting a few hours to days after exposure to the allergenic food.The pathogenesis may be related to the activation of intestinal T lymphocytes to secrete pro-inflammatory cytokines such as TNF-α and IL-4 by food allergens, leading to migration of neutrophils and eosinophils into the intestinal lumen, causing an intestinal inflammatory response and increased intestinal permeability.There is no rapid and specific diagnostic method.The diagnosis is mainly based on clinical manifestations combined with food avoidance and oral food challenge.In recent years, fecal biomarkers have been widely used as specific indicators for determining intestinal inflammation as an aid to diagnosis and condition assessment of intestinal infections and inflammatory bowel diseases, but their application in gastrointestinal allergic diseases is rarely reported.In this paper, we will focus on the significance of fecal calprotectin, fecal eosinophil-derived neurotoxin in non-IgE-mediated food allergy.
