Research advance in bone marrow metastasis in children′s neuroblastoma
10.3760/cma.j.issn.1673-4408.2022.08.001
- VernacularTitle:儿童神经母细胞瘤骨髓转移机制的研究进展
- Author:
Lihui WANG
1
;
Jingbo SHAO
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院血液肿瘤科 200040
- Keywords:
Children;
Neuroblastoma;
Bone marrow metastasis;
Cancer stem cells;
Bone marrow microenvironment;
Signaling pathways
- From:
International Journal of Pediatrics
2022;49(8):505-509
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma is the most common extracranial solid tumor for infants and young children.About 50% of patients have extensive metastasis before diagnosis, and the neuroblastoma can metastasize to bone marrow, bone, lymph node, orbit, liver and skin.Bone marrow is the most common site of neuroblastoma metastasis and recurrence.Once neuroblastoma metastasize or relapse, their survival rate will reduce significantly.The mechanism of neuroblastoma bone marrow metastasis has not been elucidated.The drug resistance of tumor cells, the interaction of bone marrow microenvironment, and the regulation of cell signaling pathways may play important roles in regulating tumor cell bone marrow metastasis.This review summarizes the research progress of bone marrow metastasis in neuroblastoma, which helps us to better understand the mechanism of interaction between neuroblastoma and the bone marrow microenvironment, and to provide new ideas for the diagnosis and treatment of patients.
