Progress on mechanism of airway mucus hypersecretion induced by mycoplasma pneumoniae infection
10.3760/cma.j.issn.1673-4408.2022.07.007
- VernacularTitle:肺炎支原体感染引起气道黏液高分泌的机制研究进展
- Author:
Yanhong DANG
1
;
Miao LI
Author Information
1. 中国医科大学附属盛京医院小儿呼吸内科，沈阳 110004
- Keywords:
Mycoplasma pneumoniae;
Airway epithelium;
Mucus hypersecretion
- From:
International Journal of Pediatrics
2022;49(7):461-464
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of chronic airway inflammatory diseases caused by airway mucus hypersecretion caused by mycoplasma pneumoniae(MP) infection is increasing year by year.In this paper, the damage of MP on airway mucosa through its adhesion, migration, community acquired respiratory distress syndrome toxin(CARDS Tx)and other virulence factors is described, which directly damages the structure and function of airway epithelium and affects the metabolism of ciated cells.It can also cause the increase of airway pro-inflammatory cytokines and the up regulation of toll-like receptor, resulting in the increase of airway mucus secretion.In addition, when MP infects airway epithelial cells, it will increase mucin(MUC)production through signal transduction pathway, which will increase the secretion of MUC5AC and lead to airway mucus hypersecretion.Controling airway mucus hypersecretion caused by MP infection can reduce the occurrence of chronic airway inflammation and helpful to the treatment of refractory MP infection.
