Progress of C3 glomerulopathy
10.3760/cma.j.issn.1673-4408.2022.07.001
- VernacularTitle:C3肾小球病的研究进展
- Author:
Aiqin SHENG
1
;
Haidong FU
;
Jianhua MAO
Author Information
1. 浙江大学医学院附属儿童医院肾内科 国家儿童临床医学研究中心 国家儿童区域医疗中心，杭州 310030
- Keywords:
C3 glomerulopathy;
Dense deposit disease;
C3 glomerulonephritis
- From:
International Journal of Pediatrics
2022;49(7):433-437
- CountryChina
- Language:Chinese
-
Abstract:
C3 glomerulopathy is a rare disease of glomeruli mediated by abnormal activation of alternative complement pathway secondary to congenital genetic defects and acquired autoantibodies.Renal biopsy is the gold standard for diagnosing C3 glomerulopathy.C3 glomerulopathy encompasses both dense deposit disease and C3 glomerulonephritis.The main glomerular immunofluorescence staining is C3, with few or without immunoglobulins deposition, which is the obvious pathological feature.The clinical manifestations of C3 glomerulopathy are usually various, with limited detection methods and therapies and poor prognosis.This article mainly reviews the progress of C3 glomerulopathy in recent years, in order to improve clinical understanding of C3 glomerulopathy, and choose individualized therapy.
