Advance in Spexin in metabolic diseases and feeding behavior
10.3760/cma.j.issn.1673-4408.2022.06.013
- VernacularTitle:Spexin与代谢性疾病和摄食行为的研究进展
- Author:
Qin SHEN
1
;
Miao HOU
;
Haitao LYU
Author Information
1. 苏州大学附属儿童医院心血管内科 215003
- Keywords:
Spexin;
Obesity;
Glucose and lipid metabolism;
Cardiovascular diseases;
Feeding behavior
- From:
International Journal of Pediatrics
2022;49(6):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Spexin is a new cytokine with a short peptide of 14 amino acids encoded by Ch12orf39, which can be identified by bioinformatics technology.The sequence of Spexin is widely expressed in various organs and is conserved during vertebrate evolution.The physiological effects of Spexin are getting increasing attention in recent years.The studies suggest Spexin plays multiple physiological functions, and the main ligands for biological effects are galanin receptor type 2 and galanin receptor type 3.Spexin palys an important biological role in energy metabolism and homeostasis, cardiovascular function and feeding behavior, and even can affect the regulation of pain and depression relief and reproductive function.This review aims to systemically summarize the Spexin and its related biological functions in metabolic diseases and feeding behavior.
