Oxidative phosphorylation in septic organ injury
10.3760/cma.j.issn.1673-4408.2022.06.007
- VernacularTitle:氧化磷酸化与脓毒症器官损伤
- Author:
Xuejian MEI
1
;
Hongjun MIAO
Author Information
1. 南京医科大学附属儿童医院重症医学/急诊科 210008
- Keywords:
Oxidative phosphorylation;
Mitochondria;
Sepsis;
Multi-organ dysfunction syndrome
- From:
International Journal of Pediatrics
2022;49(6):385-388
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory response syndrome caused by pathogenic microorganisms that infect the host.If treated improperly, it can progress to severe sepsis or even septic shock.As such, it′s one of the main reasons for the death of children in PICU.The inflammatory response of sepsis exerts great influence on a series of basic physiological functions of cells, including the oxidative phosphorylation of the mitochondria.Oxidative phosphorylation is a process during which oxygen is reduced to generate high-energy phosphate bonds in the form of adenosine triphosphate(ATP), which supplies energy for cells and produces a series of functional by-products.During sepsis, the process of oxidative phosphorylation in mitochondria undergoes a series of complex alterations, which in turn can further promote the development of septic organ injury.The present review aims to clarify the relationship between changes in oxidative phosphorylation and the impairment of various organs in sepsis.
