Application of exosomes in the diagnosis and treatment of cardiovascular diseases
10.3760/cma.j.issn.1673-4408.2022.06.001
- VernacularTitle:外泌体在心血管疾病诊治中的应用
- Author:
Xiaodong SUN
1
;
Yaqi LI
;
Lin SHI
Author Information
1. 首都儿科研究所，北京 100020
- Keywords:
Exosomes;
Heart failure;
Viral myocarditis;
Kawasaki disease;
Dilated cardiomyopathy
- From:
International Journal of Pediatrics
2022;49(6):361-364
- CountryChina
- Language:Chinese
-
Abstract:
The cardiovascular diseases, which have the increasing incidence and high mortality rate, have brought a great impact on people′s lives and health.Being lipid inclusions with 30~150 nm in diameter, exosomes can be secreted by most cells in the body, and proteins, lipids, nucleic acids and other substances derived from those cells are wrapped inside.Exosomes play a variety of biological roles in the communication between cells, such as mediating immune response, inflammatory response, cell migration and differentiation.Research on exosomes has made significant progress, and the roles of exosomes in cardiovascular diseases have consequently attracted more and more attention in recent years.The communication of exosomes between cardiomyocytes and between heart and peripheral tissues has provided new strategies for the diagnosis and treatment of cardiovascular diseases.Application of exosomes in the diagnosis and treatment of cardiovascular diseases such as heart failure, viral myocarditis, Kawasaki disease and dilated cardiomyopathy is summarized in this review.
