Progress of soluble growth stimulating express gene 2 in children respiratory diseases
10.3760/cma.j.issn.1673-4408.2022.05.003
- VernacularTitle:可溶性生长刺激表达因子-2在儿童呼吸系统疾病中的研究进展
- Author:
Liting GENG
1
;
Wenwei ZHONG
;
Jianhua ZHANG
Author Information
1. 上海交通大学医学院附属新华医院儿呼吸内科 200092
- Keywords:
Children;
Asthma;
Pneumonia;
Airway inflammation;
Soluble growth stimulating express gene 2;
Biomarker
- From:
International Journal of Pediatrics
2022;49(5):298-301
- CountryChina
- Language:Chinese
-
Abstract:
Soluble growth stimulating express gene 2(sST2)is a member of Toll/IL-1 receptor superfamily.sST2 plays an important role in the occurrence and development of respiratory diseases in children.Under normal circumstances, the concentration of sST2 in serum is very low, but the level of sST2 in serum of children with respiratory diseases such as bronchial asthma and community-acquired pneumonia increased significantly.sST2 blocks the IL-33 signaling pathway in airway inflammation, so serum sST2 levels can predict the severity of childhood asthma.sST2 can also be used as a prognostic marker of community-acquired pneumonia.This paper reviews the mechanism, clinical characteristics and prognosis of sST2 in children with asthma and community-acquired pneumonia, so as to lay a foundation for guiding clinical identification and treatment of respiratory diseases in children.
