Progress of BCR-ABL fusion gene and JAK2 V617F mutation double-positive myeloproliferative neoplasms
10.3760/cma.j.cn115356-20220407-00097
- VernacularTitle:BCR-ABL融合基因和JAK2 V617F基因突变双阳性骨髓增殖性肿瘤的研究进展
- Author:
Mingquan XING
1
;
Hongfeng GE
;
Weixia WU
;
Xiaoxing SUN
;
Lan MA
;
Qikai WANG
;
Hao HAN
Author Information
1. 亳州市人民医院血液内科,亳州 236800
- Keywords:
Myeloproliferative neoplasms;
BCR-ABL fusion gene;
JAK2 V617F gene mutation
- From:
Journal of Leukemia & Lymphoma
2022;31(10):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Myeloproliferative neoplasms (MPN) are a group of clonal disorders of hematopoietic stem cells, and JAK2 V617F gene mutation is the main basis for the diagnosis of MPN. Previous studies have shown that BCR-ABL fusion gene and JAK2 V617F gene mutation are mutually exclusive in MPN patients, but in recent years, patients with a double mutation of both genes are often reported. The article synthesizes the relevant domestic and foreign literature in recent years, and reviews the BCR-ABL fusion gene and JAK2 V617F mutation double-positive MPN.