Progress of BCR-ABL fusion gene and JAK2 V617F mutation double-positive myeloproliferative neoplasms

VernacularTitle:BCR-ABL融合基因和JAK2 V617F基因突变双阳性骨髓增殖性肿瘤的研究进展
Author: Mingquan XING ¹ ; Hongfeng GE ; Weixia WU ; Xiaoxing SUN ; Lan MA ; Qikai WANG ; Hao HAN
Author Information

1. 亳州市人民医院血液内科，亳州　236800
Keywords: Myeloproliferative neoplasms; BCR-ABL fusion gene; JAK2 V617F gene mutation
From: Journal of Leukemia & Lymphoma 2022;31(10):637-640
CountryChina
Language:Chinese
Abstract: Myeloproliferative neoplasms (MPN) are a group of clonal disorders of hematopoietic stem cells, and JAK2 V617F gene mutation is the main basis for the diagnosis of MPN. Previous studies have shown that BCR-ABL fusion gene and JAK2 V617F gene mutation are mutually exclusive in MPN patients, but in recent years, patients with a double mutation of both genes are often reported. The article synthesizes the relevant domestic and foreign literature in recent years, and reviews the BCR-ABL fusion gene and JAK2 V617F mutation double-positive MPN.