Transformation of primary myelofibrosis to B-cell acute lymphoblastic leukemia: report of 1 case and review of literature
10.3760/cma.j.cn115356-20210902-00205
- VernacularTitle:原发性骨髓纤维化转化为急性B淋巴细胞白血病1例并文献复习
- Author:
Bingjie DING
1
;
Liu LIU
;
Mengjuan LI
;
Ao XIA
;
Xuewen SONG
;
Peipei XU
;
Jianping LIU
;
Hu ZHOU
;
Yongping SONG
Author Information
1. 河南省肿瘤医院 郑州大学附属肿瘤医院血液科，郑州 450008
- Keywords:
Primary myelofibrosis;
Acute lymphoblastic leukemia;
Pathogenesis
- From:
Journal of Leukemia & Lymphoma
2022;31(10):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pathogenesis and prognosis of transformation of primary myelofibrosis (PMF) to B-cell acute lymphoblastic leukemia (B-ALL).Methods:The diagnosis and treatment process of a patient transferred from PMF to B-ALL in Affiliated Tumor Hospital of Zhengzhou University in November 2018 were retrospectively analyzed, and the relevant literature was reviewed.Results:The patient was a 64-year-old female, she was initially diagnosed with PMF, and then she developed B-ALL 17 months later after receiving treatment of prednisone, danazole, levamisole, aspirin, thalidomide and jaktinib. After induction therapy, the patient received 8 months of continuous remission, and then the reexamination showed relapse. There was no remission after reinduction therapy. The patient gave up treatment and was discharged 2 months later. JAK2 V617F gene mutation was positive before and after leukemia transformation.Conclusions:The patients with transformation of PMF to B-ALL have poor clinical prognosis and short survival time. The possible mechanism of its transformation may be related to additional genetic events or certain high-risk genes. However, the specific mechanism is still unclear, and further investigation of the etiology is needed to seek targeted treatment.
