Acute myeloid leukemia with positive TLS-ERG fusion gene: report of 9 cases and review of literature
10.3760/cma.j.cn115356-20220310-00067
- VernacularTitle:TLS-ERG融合基因阳性急性髓系白血病9例并文献复习
- Author:
Mengyuan HAN
1
;
Yehui TAN
;
Ruiping HU
;
Yangzhi ZHAO
;
Xiao DING
;
Yuying LI
;
Xiaoliang LIU
;
Hai LIN
;
Mengqing XIE
;
Yan YANG
;
Jingnan SUN
;
Sujun GAO
Author Information
1. 吉林大学第一医院血液科，长春 130021
- Keywords:
Leukemia, myeloid, acute;
Gene fusion;
Prognosis;
TLS-ERG
- From:
Journal of Leukemia & Lymphoma
2022;31(10):603-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and prognosis of acute myeloid leukemia (AML) patients with positive TLS-ERG fusion gene.Methods:The clinical data of 9 AML patients with positive TLS-ERG fusion gene in the First Hospital of Jilin University from June 2013 to August 2020 were retrospectively analyzed, and the relevant literature was reviewed.Results:Among 9 patients with positive TLS-ERG fusion gene, there were 5 males and 4 females, with a median age of 16 years old (6-40 years old). Five patients received chemotherapy alone, 3 patients received allogeneic hematopoietic stem cell transplantation (allo-HSCT), and 1 patient did not receive systematic treatment. Among 8 patients with systematic treatment, 1 patient had complete remission after the first induction chemotherapy and 5 patients had complete remission after induction therapy. The median overall survival time of 5 patients with chemotherapy alone was 1.5 months (1-11 months), of which 3 patients did not respond to the first course of treatment and died of infection, and 2 patients died after relapse. The median overall survival time of 3 patients with allo-HSCT was 16 months (13-17 months), of which 2 patients died after relapse and 1 patient had sustained molecular complete remission by the end of follow-up.Conclusions:AML with positive TLS-ERG fusion gene has low incidence rate and poor induction efficacy. Hematopoietic stem cell transplantation may partially improve the survival prognosis of patients, but it cannot overcome the adverse effect of positive TLS-ERG fusion gene on prognosis.
