Progress of long non-coding RNA H19 in hematologic malignancies

VernacularTitle:长链非编码RNA H19在血液系统恶性肿瘤中的研究进展
Author: Xiaona JIANG ¹ ; Ying LI ; Wei WANG ; Xue SHI
Author Information

1. 青岛大学附属医院血液内科，青岛　266003
Keywords: Hematologic neoplasms; Long non-coding RNA; H19; Prognosis
From: Journal of Leukemia & Lymphoma 2022;31(9):574-576
CountryChina
Language:Chinese
Abstract: With the increasing incidence of hematologic malignancies, exploring its pathogenesis and new treatment strategies has become new research directions. The development of high-throughput sequencing technology has led to the recognition of long non-coding RNA, which plays an important role in the development of life and the regulation of diseases. As the first reported long non-coding RNA, H19 acts as an oncogene to take part in various pathological processes in the growth and metastasis of tumors. However, the multiple roles of H19 in hematologic malignancies are lack of systematic summary. This article reviews the role of H19 in carcinogenesis, progression and drug resistance mechanism of hematologic malignancies, in order to provide guidance for further research.