Primary diffuse large B-cell lymphoma in cavernous sinus: report of 1 case and review of literature
10.3760/cma.j.cn115356-20220321-00079
- VernacularTitle:原发海绵窦区弥漫大B细胞淋巴瘤1例并文献复习
- Author:
Conggang HUANG
1
;
Ming LUO
;
Liang ZOU
;
Lanlan WANG
;
Yuhan BAI
;
Yan FENG
;
Jinglei WU
;
Xingwan WANG
;
Zhihua LUO
;
Faliang DUAN
Author Information
1. 武汉市第一医院神经外科 430022
- Keywords:
Lymphoma, large B-cell, diffuse;
Cavernous sinus;
Surgical resection;
Chemotherapy;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2022;31(9):551-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, treatment programs and prognosis of patients with primary diffuse large B-cell lymphoma (DLBCL) in cavernous sinus.Methods:The clinical data of a patient with primary DLBCL in cavernous sinus who were admitted to Wuhan No.1 Hospital in December 2020 were retrospectively analyzed, and the relevant literature was reviewed.Results:The patient was a 63-year-old female who underwent resection of the cavernous sinus lesion, and the pathological diagnosis was DLBCL. The patient received 6 courses of R-CHOP regimen chemotherapy, lumbar puncture + intrathecal injection of chemotherapy drugs, and twice additional rituximab immunochemotherapy, and no tumor cells were found in the results of liquid-based thin layer cytology for cerebrospinal fluid exfoliated cells; twice magnetic resonance imaging (MRI) re-examination after the operation showed no recurrence and adjacent metastasis of the tumor. The patient's symptoms were significantly improved without residual neurological sequelae.Conclusions:Primary DLBCL in cavernous sinus is rare in clinical practice, early diagnosis is crucial for the prognosis of patients, and different protein expression may indicate the prognosis. Biopsy, complete resection of the tumor under the premise of preserving important anatomical structures and functions, and standardized chemotherapy combined with intrathecal injection local chemotherapy can effectively prolong the survival time of patients and improve the quality of life.
