Chronic lymphocytic leukemia with nephrotic syndrome as the initial manifestation: report of 1 case and review of literature
10.3760/cma.j.cn115356-20210608-00141
- VernacularTitle:以肾病综合征为初始表现的慢性淋巴细胞白血病1例并文献复习
- Author:
Chengbo XU
1
;
Ruiji ZHENG
;
Jianzhen SHEN
;
Bin LIAO
;
Yan QI
;
Zesong CHEN
Author Information
1. 福建省人民医院 福建中医药大学附属人民医院血液科，福州 350004
- Keywords:
Leukemia, lymphocytic, chronic, B-cell;
Nephrotic syndrome;
Diagnosis;
Treatment
- From:
Journal of Leukemia & Lymphoma
2022;31(6):353-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical manifestation, diagnosis and treatment of chronic lymphocytic leukemia patients with renal involvement.Methods:The clinical data of a chronic lymphocytic leukemia patient with nephrotic syndrome as the initial manifestation in Fujian Provincial People's Hospital in October 2020 were retrospectively analyzed, and the related literature was reviewed.Results:The patient was a 68-year-old male with recurrent edema and foam urine as the initial manifestations, and he was diagnosed as nephrotic syndrome in the nephrology department. After treatment, the symptoms showed no significant improvement, and the lymphocyte count gradually increased. The patient was diagnosed as chronic lymphocytic leukemia in the hematology department. After ibrutinib monotherapy, the lymphocyte count and urine protein gradually decreased to normal levels, and the clinical efficacy evaluation of the patient was complete remission at the end of follow-up.Conclusions:Chronic lymphocytic leukemia with nephrotic syndrome as the initial manifestation is rare, and the clinical presentations are variable. Early diagnosis is the guarantee of successful treatment. The efficacy and safety of first-line Bruton tyrosine kinase inhibitor monotherapy are good.
