Mechanisms of Saponins in Chinese Medicinals Against Diabetic Nephropathy： A Review
10.13422/j.cnki.syfjx.20222337
- VernacularTitle:中药皂苷类成分干预糖尿病肾病作用机制研究进展
- Author:
Peng YANG
1
;
Tonghua LIU
2
;
Lili WU
2
;
Lingling QIN
2
;
Chengfei ZHANG
2
;
Chuan PENG
3
;
Qiue ZHANG
2
Author Information
1. The First Clinical Medical College of Shaanxi University of Chinese Medicine，Xianyang 712046， China
2. Key Laboratory of Chinese Medicine and Health Sciences，Ministry of Education， Beijing University of Chinese Medicine，Beijing 100029，China
3. Chengdu University of Chinese Medicine，Chengdu 610075，China
- Publication Type:Journal Article
- Keywords:
saponins in Chinese medicinals;
diabetic nephropathy;
signaling pathway： mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(4):263-271
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN）， the most feared microvascular complication of diabetes and one of the most common and serious complications of diabetes， is the major cause of end-stage renal disease worldwide， leading cause of morbidity and mortality in patients with diabetes， and the main non-communicable cause of death worldwide. There are many types of saponins， which are the main bioactive components of various Chinese medicinals. They have various pharmacological activities such as lowering blood glucose and blood lipids， improving insulin resistance， anti-inflammation， anti-oxidative stress， anti-tumor， and immune modulation. In recent years， it has been frequently verified that the saponins in Chinese medicinals have definite effect in regulating DN， showing multi-target， multi-pathway， multi-system， multi-effect characteristics. Thus， they have broad prospects in the prevention and treatment of this disease. There has been an explosion of research on the treatment of DN with saponins in Chinese medicinals in vivo and in vitro， but there is a lack of systematic and comprehensive summary. Therefore， this study summed up the studies of saponins in Chinese medicinals in the intervention of DN and summarized the mechanisms such as improving glucolipid metabolism， inhibiting oxidative stress， anti-inflammation， anti-apoptosis， regulating autophagy， anti-fibrosis， and protecting podocytes， with a view to providing ideas and references for the development of drugs related to DN.
