Autophagy Regulated by Chinese Medicine Monomers in Embryo Implantation： A Review
10.13422/j.cnki.syfjx.20230112
- VernacularTitle:中药单体调控自噬干预胚胎植入的研究进展
- Author:
Zhiyu ZHOU
1
;
Wei SHI
2
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250014 ，China
2. Affiliated Hospital of Shandong University of TCM， Jinan 250011， China
- Publication Type:Journal Article
- Keywords:
embryo implantation;
autophagy;
Chinese medicine monomers;
influence mechanism;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(4):253-262
- CountryChina
- Language:Chinese
-
Abstract:
Embryo implantation is one of the most critical steps in the reproductive process. The failure of embryo implantation to continue development is one of the important reasons leading to infertility. The success of embryo implantation depends on the high receptivity of endometrium and the embryo with implantation ability. Autophagy is a process in which cytoplasm， organelles， and inclusions are absorbed by double-membrane vesicles and transported to lysosomes for degradation and recycling， which is a way to maintain the homeostasis. A large amount of evidence have shown that autophagy plays an important role in all aspects of embryo implantation. Based on this， this paper explored the relationship between autophagy and endometrial receptivity and embryo implantation ability. According to the latest research progress， this paper combed 5 mechanisms （promotion of decidualization of endometrial stromal cells， promotion of apoptosis， regulation of hormone levels， coordination of inflammation， and promotion of ovulation） of 14 kinds of Chinese medicine monomers， including emodin， catalpol， paeoniflorin， resveratrol， folic acid， zearalenone， curcumin， wogonin， quercetin， chrysin， berberine， apigenin， phisetine， and kaempferol， in regulating different links of autophagy intervention in embryo implantation. This paper is expected to provide references and ideas for future Chinese medicine monomers to improve the success rate of embryo implantation.
