Matrix Metalloproteinase-2 Associated with Cerebral Ischemic Injury and Recovery (review)
- VernacularTitle:基质金属蛋白酶-2与脑缺血损伤及修复
- Author:
Yuewen MA
;
Lin QIANG
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase-2, cerebral ischemia, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(5):440-442
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase-2 (MMP-2), which is a member of MMP family, can degrade extracellular matrix. During the early stage of cerebral ischemia, MMP-2 degrades endothelial tight junction and basal lamina resulting in the opening of blood-brain barrier. During the late stage, MMP-2 promotes neurovascular regeneration and the recovery of the damaged brain tissue.
