Modeling of Acute Deep Venous Thrombosis in Rabbits
- VernacularTitle:建立新西兰白兔深静脉血栓模型的实验研究
- Author:
Yujiang ZHENG
;
Qing TANG
;
Fangge DENG
;
Hao ZHANG
- Publication Type:Journal Article
- Keywords:
deep venous thrombosis, animal model, rabbits
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(5):437-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a model of deep venous thrombosis (DVT) in rabbits. Methods Animal models of venous thrombosis were made by blocking venous flow with a vascular clamp temporarily, injuring the vascular wall, and injecting thrombin in the distal vein in one side of rabbits. Then fixed the hip and knee joints of the operated sides in the flection position with plaster. 48 h later, the femoral veins on both sides were examined with the ultrasonography and pathology. Results All the rabbits survived after operation. The ultrasonography showed that the femoral veins on both sides were virtually anechoic. However, the veins on the operated sides couldn't be compressed and no flow was detected, the control sides were just the reverse. The veins on the operated side were filled with thrombus which had not adhered on the wall, but no thrombosis occurred in the control side. Conclusion A model of DVT was established in rabbits.
