Expressions of Transforming Growth Factor β2 and Smad3 in Human Gliomas with Different Pathologic Grade Proliferation and Its Clinical Significance
- VernacularTitle:人脑胶质瘤中转化生长因子β2、Smad3 蛋白表达及临床意义1
- Author:
Wei SU
;
Fusheng LIU
;
Guidong ZHU
;
Zhongli JIANG
;
Guishan JIN
;
Qi CHAI
;
Ze CAO
- Publication Type:Journal Article
- Keywords:
glioma, transforming growth factor β2, Smad3, immunhistochemistry
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(5):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Transforming Growth Factorβ2 (TGF-β2) and Smad3 in human gliomas associated with pathologic grading. Methods The expressions of TGFβ2 and Smad3 protein were detected with SP immunhistochemistry in 80 human glioma specimens. The Kapan-Meier survival curves of progression-free survival time and overall survival time in different expression levels was compared with log-rank. Results The expression of TGFβ2 and Smad3 correlated with the pathological grading (r=0.545, r=0.570, P<0.01). Both progression-free survival time and overall survival time were significantly different between low expression group and high expression group (P<0.05). Conclusion Both TGF-β2 and Smad3 correlate well with the occurrence and differentiation of human gliomas,which help for the diagnosis, treatment and prognosis judgment．
