Advances in the study of congenital immune mechanisms mediated by modifiable cardiovascular risk factors for atherosclerosis
- VernacularTitle:可改变的心血管危险因素介导动脉粥样硬化的先天性免疫机制研究进展
- Author:
Wentao LI
1
;
Fanghui LI
1
;
Dongze LI
2
;
Yu JIA
2
;
Zhi WAN
2
;
Rui ZENG
1
Author Information
1. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
2. Emergency Department, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Innate immunity;
atherosclerosis;
modifiable cardiovascular risk factor;
bone marrow hematopoiesis;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(01):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Obesity, sleep disorders, psychological stress, sedentary are modifiable cardiovascular risk factors. There is growing evidence that these risk factors may accelerate the chronic inflammatory process of atherosclerosis and lead to myocardial infarction. Studies on the role of immune cells and their related immune mechanisms in atherosclerosis have shown that the above modifiable risk factors can affect the hematopoiesis of the bone marrow system, affect the production of immune cells and phenotypes, and then affect the progress of atherosclerosis. This review will focus on the effects of modifiable cardiovascular risk factors on the progression of atherosclerosis through the role of the innate immune system.
