Therapeutic effects of estrogen-intervened EPCs transplantation on diabetic ischemic stroke rats
10.12206/j.issn.2097-2024.202111111
- VernacularTitle:雌激素干预的EPCs移植对糖尿病缺血性脑卒中大鼠的治疗作用
- Author:
Yafen DONG
1
;
Jian WANG
1
;
Ye CHEN
1
;
Shushu LI
1
;
Helong LIU
1
;
Yan QIU
1
Author Information
1. Shanghai Pudong New Area People’s Hospital, Shanghai 201200, China.
- Keywords:
estrogen;
EPCs transplantation;
diabetic ischemic stroke;
neovascularization;
homing
- From:
Journal of Pharmaceutical Practice
2023;41(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects of estrogen-intervened endothelial progenitor cells( EPCs) transplantation on diabetic ischemic stroke rats. Methods PKH26-labeled diabetic EPCs and estrogen-intervened diabetic EPCs were injected into rats via the tail vein 24 h after cerebral ischemia. Cerebral ischemic volume, behavioral changes, ischemic site vascularization and homing of EPCs were measured 3 d after EPCs injection. Results Compared with diabetic ischemic rats, estrogen-intervened EPCs transplantation had reduced infarct volumes, improved behavioral scores and ischemic site revascularization and promoted homing of EPCs to sites of injury(P<0.05). Conclusion Estrogen-intervened EPCs transplantation had a better therapeutic effect on diabetic ischemic stroke by promoting EPCs homing to injury site and EPCs-medicated neovascularization .
