Imaging characteristics and postoperative pathological analysis of bronchiolar adenoma
- VernacularTitle:细支气管腺瘤的影像学特征及术后病理分析
- Author:
Lei SU
1
;
Yi ZHANG
1
;
Yan GAO
2
;
Bing WEI
3
;
Tengteng WANG
1
;
Yuanbo LI
1
;
Kun QIAN
1
;
Leiming WANG
4
;
Xiuqin WEI
5
Author Information
1. Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, P. R. China
2. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, P. R. China
3. Department of Pulmonary and Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, P. R. China
4. Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, P. R. China
5. Endoscopic Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, 100144, P. R. China
- Publication Type:Journal Article
- Keywords:
Bronchiolar adenoma;
video-assisted thoracic surgery;
imaging features;
postoperative pathology
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2023;30(01):78-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the pathological manifestations and imaging characteristics of bronchiolar adenoma (BA). Methods The clinical data of 11 patients with BA who received surgeries in our hospital from January 2019 to September 2020 were retrospectively analyzed, including 5 males and 6 females aged 40-73 (62.40±10.50) years. The intraoperative rapid freezing pathological diagnosis, postoperative pathological classification, cell growth pattern, nuclear proliferation index Ki-67 and other immunohistochemical staining combined with preoperative chest CT imaging characteristics were analyzed. Results The average preoperative observation time was 381.10±278.28 d. The maximum diameter of imaging lesions was 5-27 (10.27±6.34) mm. Eight (72.7%) patients presented with irregular morphology of heterogeneous ground-glass lesions, and 3 (27.3%) patients presented with pure ground-glass lesions. There were 10 (90.9%) patients with vascular signs, 8 (72.7%) patients with vacuolar signs, 1 (9.1%) patient with bronchus sign, 3 (27.3%) patients with pleural traction and 9 (81.8%) patients with burr/lobular sign. The surgical methods included sub-lobectomy in 10 patients and lobectomy in 1 patient. Five (45.5%) patients were reported BA by intraoperative frozen pathology. The postoperative pathological classification included 8 patients with distal-type and 3 patients with proximal-type, and the maximum diameter of the lesions was 4-20 (8.18±5.06) mm. Eight (72.7%) patients showed characteristic bilayer cell structure under microscope, and 10 (90.9%) patients showed thyroid transcription factor 1 expression in pathological tissues. The expression of NapsinA in intracavity cells was found in 9 (81.8%) patients. The Ki-67 index of the lesion tissue was 1%-5% (3.22%±1.72%). Conclusion The pathological features and imaging findings of BA confirm the premise that BA is a neoplastic lesion. However, to identify BA as a benign or inert tumor needs more clinical data and evidence of molecular pathological studies.
