Content determination and chemometric analysis of 11 components in Xueli zhike syrup
- VernacularTitle:雪梨止咳糖浆中11个成分的含量测定及化学计量学分析
- Author:
Qianqian PANG
1
;
Weiye YUE
2
;
Keqin LIU
1
;
Jianhua TANG
1
Author Information
1. Dept. of Pharmacy，the First Affiliated Hospital of Hebei North University，Hebei Zhangjiakou 075061，China
2. School of Graduate，Hebei North University，Hebei Zhangjiakou 075031，China
- Publication Type:Journal Article
- Keywords:
Xueli zhike syrup;
HPLC;
chemometric;
multi-index;
quality control;
euscaphic acid;
amygdalin;
praeruptorin A
- From:
China Pharmacy
2023;34(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To determine the contents of 11 components in Xueli zhike syrup， establish its chemometric method and provide reference for its quality control. METHODS HPLC method was established to simultaneously determine the contents of amygdalin， deapi-platycoside E， platycoside E， platycodin D3， euscaphic acid， tormentic acid， maslinic acid， corosolic acid， praeruptorin A， praeruptorin B and praeruptorin E in 12 batches of Xueli zhike syrup. The quality evaluation of 12 batches of samples was performed by chemometrics. RESULTS The 11 components had good linear relationships within their respective ranges （r≥0.999 1）； RSDs of precision， reproducibility and stability （24 h） tests were all lower than 2.00%. The average recovery rates ranged 96.90%-100.01% （RSDs were all lower than 2.00%）. Cluster analysis showed that 12 batches of samples were clustered into 3 groups. Principal component analysis showed that the first two principal components could represent 88.53% information of 11 components in Xueli zhike syrup. Partial least squares-discrimination analysis showed that euscaphic acid， amygdalin and praeruptorin A were the main potential markers affecting the quality of Xueli zhike syrup. CONCLUSIONS The established method can be used to control the quality of Xueli zhike syrup.
