Predictive value of cystatin C on acute kidney injury after total aortic arch replacement: A retrospective cohort study
- VernacularTitle:胱抑素 C 预测全弓置换术后急性肾损伤的回顾性队列研究
- Author:
Jiaxin LI
1
,
2
;
Miaoxian FANG
1
,
2
;
Liming LEI
1
,
2
;
Weiping XIONG
1
,
2
;
Chunbo CHEN
2
,
3
,
4
,
5
,
6
,
7
Author Information
1. Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People'
2. s Hospital, Guangdong Cardiovascular Institute, Guangzhou, 510080, P. R. China
3. 1.Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People'
4. 2. Department of Critical Care Medicine, Guangdong Provincial People'
5. s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, P. R. China
6. 3. Department of Critical Care Medicine, Maoming People'
7. s Hospital, Maoming, 525000, Guangdong, P. R. China
- Publication Type:Journal Article
- Keywords:
Total aortic arch replacement;
acute kidney injury;
cystatin C
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(12):1625-1630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors and predictive value of acute kidney injury (AKI) after total aortic arch replacement. Methods The clinical data of patients undergoing total aortic arch replacement in our hospital from January 2018 to June 2019 were retrospectively analyzed, and patients receiving preoperative renal replacement therapy and missing creatinine values were excluded. According to whether postoperative AKI occurred, patients were divided into an AKI group and a control group. The univariate and multivariate analyses (logistic regression) were used to explore the independent risk factors of AKI. The receiver operating characteristic curve was used to analyze the significant factors in predicting the occurrence of AKI after total aortic arch replacement. Results A total of 162 patients were included in the study, including 135 (83.3%) males and 27 (16.7%) females, with an average age of 52.61±9.90 years (range: 22 to 73 years). The incidence of AKI was 68.5% (n=111). The results of univariate and multivariate analyses showed that the postoperative serum cystatin C level (OR=76.145, 95%CI 15.575-372.260, P<0.01) was an independent risk factor for AKI after total aortic arch replacement. When its cut-off value was above 1.08 mg/L, the specificity for predicting postoperative AKI was 70.59%, and the sensitivity was 85.59%. Conclusion The postoperative cystatin C level is an independent risk factor for AKI after total aortic arch replacement and has predictive value.
